主要类型

内在膜蛋白是整合于膜上的蛋白质，总是与膜结合在一起。可以定义为需要通过人工加入去垢剂（如SDS或Triton X-100）或其他非极性溶剂才能够从膜中分离出来的蛋白质。内在膜蛋白还可以根据与双分子膜之间结合关系的差异细分为：

外周膜蛋白是能够暂时与膜或内在膜蛋白结合的蛋白质，主要是通过疏水、静电和其他非共价相互作用来进行结合，这种结合可以通过加入极性试剂，如高pH或高盐溶液来破坏。

内在膜蛋白和外周膜蛋白都可以被翻译后修饰，如加上脂肪酸链和异戊二烯化（Prenylation），有助于与脂膜的结合。

参见

内在膜蛋白

外周膜蛋白

离子泵

运输蛋白

离子通道

受体

参考文献

延伸阅读

Protein-lipid interactions (Ed. L.K. Tamm) Wiley, 2005.

Popot J-L. and Engelman D.M. 2000. Helical membrane protein folding, stability, and evolution. Annu. Rev. Biochem. 69: 881-922.

Bowie J.U. 2005. Solving the membrane protein folding problem. Nature 438: 581-589.

Cho, W. and Stahelin, R.V. 2005. Membrane-protein interactions in cell signaling and membrane trafficking. Annu. Rev. Biophys. Biomol. Struct. 34: 119–151.

Goni F.M. 2002. Non-permanent proteins in membranes: when proteins come as visitors. Mol. Membr. Biol. 19: 237-245.

Johnson J.E. and Cornell R.B. 1999. Amphitropic proteins: regulation by reversible membrane interactions. Mol. Membr. Biol. 16: 217-235.

Seaton B.A. and Roberts M.F. Peripheral membrane proteins. pp. 355-403. In Biological Membranes (Eds. K. Mertz and B.Roux), Birkhauser Boston, 1996.

外部链接

组织

Membrane Protein Structural Dynamics Consortium

Transmembrane Protein Centerat University of Wisconsin-Madison

膜蛋白质数据库

List of transmembrane proteins of known 3D structure

TCDB- Transporter Classification database

Orientations of Proteins in Membranes (OPM) database3D structures of integral and peripheral membrane proteins arranged in the lipid bilayer

Membrane PDBDatabase of 3D structures of integral membrane proteins and hydrophobic peptides with an emphasis on crystallization conditions

Protein Data Bank of Transmembrane Proteins3D models of all transmembrane proteins currently in PDB. Approximate positions of membrane boundary planes were calculated for each PDB entry.

TransportDBGenomics-oriented database of transporters from TIGR

Membrane targeting domains (MeTaDoR)

延伸阅读

（英文） The Human Membrane Proteome- A comprehensive article covering the transmembrane protein component of the human proteome

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