病毒之组成及形态

组织培养或水痘液的病毒颗粒有C及M两型 (Cubed, Mulberry)。C型为砖块型有一宽界明显的外膜，中心电子密度较大。Mulberry(桑椹)型简称M型，外表有纺锤丝状排列。M型颗粒之中心常凹陷，代表两个圆形侧体(lateral body)，核仁及双链DNA基因，其功用目前尚不十分明了。所有的痘病毒都于细胞质内增生，造成嗜酸性质内包涵体。痘病毒通常感染上皮细胞造成丘疹水及脓。

其他的病如绵羊痘(sheep pox)及羊接触传染性化脓性口炎(orf)及牛痘(cow pox)为其它引起动物发疹的病毒，也会传染给人类，除了parapox属外，所有的痘病毒都是170~250×300~450nm之砖形颗粒，表面有纺锤丝状的结构。parapox(orf等)较呈卵形，表面丝状排列为规则之螺旋型，平均仅为150×200nm所有痘病毒的内部结构大致上都是一致的。

其它病毒相关讯息

根据最新的研究痘病毒科可能属于核质巨DNA病毒。

参考书目

Advances in Imaging and Electron Physics (Advances in Imaging and Electron Physics, Vol 111, Peter W. Hawkes, Academic Pr; 1999

Advances in Scanning probe Microscopy (Advances in Materials Research, 2),by T. Sakurai, Y. Watanabe, Springer Verlag; 2000.

Artifacts in Biological Electron Microscopy, Richard F.E. Crang, Karen L. Klomparens, Plenum Pub Corp; Facsimile edition,1988.

Biological Electron Microscopy : Theory, Techniques, and Troubleshooting, Michael J. Dykstra, Plenum Pub Corp, 1992.

Fields – Virology; David M. Knipe, Peter M. Howley, dia Griffin, et al., Lippincott Williams & Wilkins, 4th edition; 2001

Fundamental Virology, David M. Knipe, Peter M. Howley, Diane E. Griffin, robe Lamb, Lippincott Williams & Wilkins Publishers; 4th edition,2001

Origin and Evolution of Viruses;Esteban Domingo, Robert G. Webster, John Holland, es Domingo, et al., Academic Pr, 1999.

Veterinary Virology, Frederick A. Murphy, et al. Academic Pr; 1999, 3rd edition

Virus Taxonomy Deluxe: Classification and Nomenclature of Viruses: Seventh Report of the International Committee on Taxonomy of Viruses by International Committee on Taxonomy of Viruses, C. M. Fauquet, M.H.V. van Regenmortel, D.H.L. Bishop, American Academy of Pediatrics, t edition, 2001.

Virus Taxonomy: Classification and Nomenclature of Viruses: Seventh Report of the International Committee on Taxonomy of Viruses, International Committee on Taxonomy of Viruses, et al, Academic Pr; t edition; 2000

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